The tell-tale heart: A case of recurrent vulvar carcinoma with cardiac metastasis and review of literature
Identifieur interne : 000078 ( Main/Exploration ); précédent : 000077; suivant : 000079The tell-tale heart: A case of recurrent vulvar carcinoma with cardiac metastasis and review of literature
Auteurs : Syed Imran Mustafa Jafri [États-Unis] ; Naveed Ali [États-Unis] ; Salman Farhat [États-Unis] ; Faizan Malik [États-Unis] ; Mark Shahin [États-Unis]Source :
- Gynecologic Oncology Reports [ 2352-5789 ] ; 2017.
Abstract
A 50-year-old female was diagnosed with vulvar cancer treated with left partial vulvectomy and bilateral lymphadenectomy. Ten months after her surgery, she presented with increased labial swelling, pain and discharge. Biopsy confirmed recurrence of squamous cell vulvar carcinoma. Incidentally, on restaging radiographic scans, she was found to have a large right ventricular mass which, after surgical debulking, was shown to be a squamous cell cancer of vulvar origin. She was commenced on chemotherapy with carboplatin and paclitaxel along with concurrent radiation therapy. Restaging PET scan showed persistent metastatic disease. She was switched to Cisplatin/Taxol after having hypersensitivity reaction to Carboplatin. She received 5 cycles with progression of disease in the follow up scans. She then received Nivolumab for 2 cycles. The patient then opted for comfort directed care given worsening functional status and progression of disease on repeat imaging. Secondary cardiac tumors are very rare and not extensively studied in oncology. Therefore, optimal management is not entirely clear. It is extremely rare for vulvar cancer to metastasize to the heart and only two cases have been reported in the literature. However, vulvar cancer metastasizing to the right ventricular cavity and endocardium has not been described before. We believe that this is the first ever such reported case.
Url:
DOI: 10.1016/j.gore.2017.06.004
PubMed: 28664179
PubMed Central: 5479938
Affiliations:
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id="af0005">Abington-Jefferson Health, Department of Internal Medicine, 1200 Old York Road, Abington, PA 19001, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abington-Jefferson Health, Department of Internal Medicine, 1200 Old York Road, Abington, PA 19001</wicri:regionArea><wicri:noRegion>PA 19001</wicri:noRegion></affiliation></author><author><name sortKey="Farhat, Salman" sort="Farhat, Salman" uniqKey="Farhat S" first="Salman" last="Farhat">Salman Farhat</name><affiliation wicri:level="1"><nlm:aff id="af0005">Abington-Jefferson Health, Department of Internal Medicine, 1200 Old York Road, Abington, PA 19001, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abington-Jefferson Health, Department of Internal Medicine, 1200 Old York Road, Abington, PA 19001</wicri:regionArea><wicri:noRegion>PA 19001</wicri:noRegion></affiliation></author><author><name sortKey="Malik, Faizan" sort="Malik, Faizan" uniqKey="Malik F" first="Faizan" last="Malik">Faizan Malik</name><affiliation wicri:level="1"><nlm:aff id="af0005">Abington-Jefferson Health, Department of Internal Medicine, 1200 Old York Road, Abington, PA 19001, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abington-Jefferson Health, Department of Internal Medicine, 1200 Old York Road, Abington, PA 19001</wicri:regionArea><wicri:noRegion>PA 19001</wicri:noRegion></affiliation></author><author><name sortKey="Shahin, Mark" sort="Shahin, Mark" uniqKey="Shahin M" first="Mark" last="Shahin">Mark Shahin</name><affiliation wicri:level="1"><nlm:aff id="af0010">Abington-Jefferson Health, Hanjani Institute for Gynecologic Oncology, 1200 Old York Road, Abington, PA 19001, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abington-Jefferson Health, Hanjani Institute for Gynecologic Oncology, 1200 Old York Road, Abington, PA 19001</wicri:regionArea><wicri:noRegion>PA 19001</wicri:noRegion></affiliation></author></analytic><series><title level="j">Gynecologic Oncology Reports</title><idno type="eISSN">2352-5789</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A 50-year-old female was diagnosed with vulvar cancer treated with left partial vulvectomy and bilateral lymphadenectomy. Ten months after her surgery, she presented with increased labial swelling, pain and discharge. Biopsy confirmed recurrence of squamous cell vulvar carcinoma. Incidentally, on restaging radiographic scans, she was found to have a large right ventricular mass which, after surgical debulking, was shown to be a squamous cell cancer of vulvar origin. She was commenced on chemotherapy with carboplatin and paclitaxel along with concurrent radiation therapy. Restaging PET scan showed persistent metastatic disease. She was switched to Cisplatin/Taxol after having hypersensitivity reaction to Carboplatin. She received 5 cycles with progression of disease in the follow up scans. She then received Nivolumab for 2 cycles. The patient then opted for comfort directed care given worsening functional status and progression of disease on repeat imaging. Secondary cardiac tumors are very rare and not extensively studied in oncology. Therefore, optimal management is not entirely clear. It is extremely rare for vulvar cancer to metastasize to the heart and only two cases have been reported in the literature. However, vulvar cancer metastasizing to the right ventricular cavity and endocardium has not been described before. We believe that this is the first ever such reported case.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Agrawal, A" uniqKey="Agrawal A">A. Agrawal</name></author><author><name sortKey="Wood, K A" uniqKey="Wood K">K.A. Wood</name></author><author><name sortKey="Giede, C K" uniqKey="Giede C">C.K. Giede</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ansink, A" uniqKey="Ansink A">A. Ansink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Artioli, G" uniqKey="Artioli G">G. Artioli</name></author><author><name sortKey="Borgato, L" uniqKey="Borgato L">L. 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Reardon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maggino, T" uniqKey="Maggino T">T. Maggino</name></author><author><name sortKey="Landoni, F" uniqKey="Landoni F">F. Landoni</name></author><author><name sortKey="Sartori, E" uniqKey="Sartori E">E. Sartori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Motwani, M" uniqKey="Motwani M">M. Motwani</name></author><author><name sortKey="Kidambi, A" uniqKey="Kidambi A">A. Kidambi</name></author><author><name sortKey="Herzog, B A" uniqKey="Herzog B">B.A. Herzog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reynen, K" uniqKey="Reynen K">K. Reynen</name></author><author><name sortKey="Kockeritz, U" uniqKey="Kockeritz U">U. Köckeritz</name></author><author><name sortKey="Strasser, R H" uniqKey="Strasser R">R.H. Strasser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsuchida, K" uniqKey="Tsuchida K">K. Tsuchida</name></author><author><name sortKey="Oike, T" uniqKey="Oike T">T. Oike</name></author><author><name sortKey="Ohtsuka, T" uniqKey="Ohtsuka T">T. Ohtsuka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woelber, L" uniqKey="Woelber L">L. Woelber</name></author><author><name sortKey="Trillsch, F" uniqKey="Trillsch F">F. Trillsch</name></author><author><name sortKey="Kock, L" uniqKey="Kock L">L. Kock</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Jafri, Syed Imran Mustafa" sort="Jafri, Syed Imran Mustafa" uniqKey="Jafri S" first="Syed Imran Mustafa" last="Jafri">Syed Imran Mustafa Jafri</name></noRegion><name sortKey="Ali, Naveed" sort="Ali, Naveed" uniqKey="Ali N" first="Naveed" last="Ali">Naveed Ali</name><name sortKey="Farhat, Salman" sort="Farhat, Salman" uniqKey="Farhat S" first="Salman" last="Farhat">Salman Farhat</name><name sortKey="Malik, Faizan" sort="Malik, Faizan" uniqKey="Malik F" first="Faizan" last="Malik">Faizan Malik</name><name sortKey="Shahin, Mark" sort="Shahin, Mark" uniqKey="Shahin M" first="Mark" last="Shahin">Mark Shahin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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